Gene expression profile may ID renal cell carcinoma pts unlikely to benefit from nivolumab

(American Association for Cancer Research) Renal cell carcinomas positive for the protein PD-L1 from patients who did not respond to treatment with the anti-PD-1 therapeutic nivolumab (Opdivo) had significantly higher expression of genes associated with metabolism, compared with PD-L1-positive tumors from patients who did respond to nivolumab.